Insulin as a Growth Hormone

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Effect of Six Months of Aerobic Exercise on Serum Levels of Insulin, Growth Hormone and Insulin-Like Growth Hormone 1 in Sedentary Obese Women

ABSTRACT            Background and Objectives: Inactivity, obesity and hormone disorders can lead to various diseases in obese and non-athletic individuals. The objective of this study was to investigate effects of six months of aerobic exercise on serum levels of insulin, growth hormone (GH) and insulin-like growth hormone 1 (IGF-1) in sedent...

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Insulin-like growth factor 1 (IGF-1): a growth hormone.

AIM To contribute to the debate about whether growth hormone (GH) and insulin-like growth factor 1 (IGF-1) act independently on the growth process. METHODS To describe growth in human and animal models of isolated IGF-1 deficiency (IGHD), such as in Laron syndrome (LS; primary IGF-1 deficiency and GH resistance) and IGF-1 gene or GH receptor gene knockout (KO) mice. RESULTS Since the descri...

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Effect of growth hormone on insulin secretion.

MALAISE, WILLY J., FRANCXNE MALAISSE-LAGAE, SUZANNE KING, ANII PETER H. WRIGHT. Efect of growth hormone on insulin secretion. Am. J. Physiol. 215(2) : 4-23-428. 1968.pInsulin secretion by pancreatic tissue or isolated islets of the normal rat is not affected by addition of ovine or rat growth hormone to the incubation medium. Pancreatic tissue removed from hypophysectomized rats secretes an abn...

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Basal insulin, glucagon, and growth hormone replacement.

Conclusions drawn from the pancreatic (or islet) clamp technique (suppression of endogenous insulin, glucagon, and growth hormone secretion with somatostatin and replacement of basal hormone levels by intravenous infusion) are critically dependent on the biological appropriateness of the selected doses of the replaced hormones. To assess the appropriateness of representative doses we infused sa...

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Insulin reverses growth hormone-induced homologous desensitization.

Growth hormone (GH) is secreted in a pulsatile pattern to promote body growth and metabolism. GH exerts its function by activating several signaling pathways, including JAK2/STAT and MEK/ERK. ERK1/2 activation by GH plays important roles in gene expression, cell proliferation, and growth. We previously reported that in rat H4IIE hepatoma cells after an initial GH exposure, a second GH exposure ...

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ژورنال

عنوان ژورنال: BMJ

سال: 1953

ISSN: 0959-8138,1468-5833

DOI: 10.1136/bmj.2.4832.353